Peptide Information

General Information of This Peptide
Peptide ID
BTDP000463
Peptide Name
Potassium channel toxin ShK (K9[Nal])
Symonym
Potassium channel toxin ShK (K9[Nal])
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
RSCIDTIPKSRCTAFKCKHSMKYRLSFCRKTCGTC
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Mutant Sequence
RSCIDTIP[Nal]SRCTAFQCKHSMKYRLSFCRKTCGTC
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Sequence Length
35
Mass(Da)
4124
Sequence Removed Signal Peptide
RSCIDTIP[Nal]SRCTAFQCKHSMKYRLSFCRKTCGTC
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 IC50
0.011 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
0.472 nM
 .
Blocker
 [1]
References
Ref 1 Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3. J Med Chem. 2015 Sep 10;58(17):6784-802. doi: 10.1021/acs.jmedchem.5b00495. Epub 2015 Aug 31.
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