Peptide Information

General Information of This Peptide
Peptide ID
BTDP000212
Peptide Name
GPTX1 (Val33Ala)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Mutant Sequence
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYAF
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Sequence Length
34
Mass(Da)
4081
Sequence Removed Signal Peptide
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYAF
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Disulfide Bond
2-17;9-23;16-30
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
170 nM
 . . [1]
 Target Info    Nav1.5 IC50
>5 μM
 . . [2]
 Target Info    Nav1.4 IC50
4.5 ± 0.5 μM
 . . [3]
References
Ref 1 Utilization of blood cultures in Danish hospitals: a population-based descriptive analysis. Clin Microbiol Infect. 2015 Apr;21(4):344.e13-21. doi: 10.1016/j.cmi.2014.11.018. Epub 2014 Nov 23.
Ref 2 Impact of a hospital-wide multifaceted programme for reducing carbapenem-resistant Enterobacteriaceae infections in a large teaching hospital in northern Italy. Clin Microbiol Infect. 2015 Mar;21(3):242-7. doi: 10.1016/j.cmi.2014.10.020. Epub 2014 Nov 11.
Ref 3 Regional distribution of nosocomial infections due to ESBL-positive Enterobacteriaceae in Germany: data from the German National Reference Center for the Surveillance of Nosocomial Infections (KISS). Clin Microbiol Infect. 2015 Mar;21(3):255.e1-5. doi: 10.1016/j.cmi.2014.07.015. Epub 2014 Oct 29.
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