Peptide Information

General Information of This Peptide
Peptide ID
BTDP000191
Peptide Name
GPTX1 (Ser24Ala)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Mutant Sequence
DCLGFMRKCIPDNDKCCRPNLVCARTHKWCKYVF
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Sequence Length
34
Mass(Da)
4065
Sequence Removed Signal Peptide
DCLGFMRKCIPDNDKCCRPNLVCARTHKWCKYVF
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Disulfide Bond
2-17;9-23;16-30
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
470 nM
 . . [1]
 Target Info    Nav1.5 IC50
>4.7 μM
 . . [2]
 Target Info    Nav1.4 IC50
1.9 ± 0.6 μM
 . . [3]
References
Ref 1 Therapies targeting oxidative stress for human diseases: where are we now?. Curr Pharm Biotechnol. 2015;16(3):195. doi: 10.2174/156802661503150202123740.
Ref 2 Acute pulmonary exacerbation and lung function decline in patients with cystic fibrosis: high-mobility group box 1 (HMGB1) between inflammation and infection. Clin Microbiol Infect. 2015 Apr;21(4):368.e1-9. doi: 10.1016/j.cmi.2014.11.004. Epub 2014 Nov 15.
Ref 3 Factors associated with subsequent nontuberculous mycobacterial lung disease in patients with a single sputum isolate on initial examination. Clin Microbiol Infect. 2015 Mar;21(3):250.e1-7. doi: 10.1016/j.cmi.2014.08.025. Epub 2014 Oct 29.
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