Peptide Information

General Information of This Peptide
Peptide ID
BTDP000188
Peptide Name
GPTX1 (Pro19Ala)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Mutant Sequence
DCLGFMRKCIPDNDKCCRANLVCSRTHKWCKYVF
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Sequence Length
34
Mass(Da)
4081
Sequence Removed Signal Peptide
DCLGFMRKCIPDNDKCCRANLVCSRTHKWCKYVF
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Disulfide Bond
2-17;9-23;16-30
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
90 nM
 . . [1]
 Target Info    Nav1.5 IC50
>20 μM
 . . [2]
 Target Info    Nav1.4 IC50
1.5 ± 0.3 μM
 . . [3]
References
Ref 1 Application of ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry to identify curcumin metabolites produced by human intestinal bacteria. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 15;985:38-47. doi: 10.1016/j.jchromb.2015.01.014. Epub 2015 Jan 24.
Ref 2 Toscana virus meningitis case in Switzerland: an example of the ezVIR bioinformatics pipeline utility for the identification of emerging viruses. Clin Microbiol Infect. 2015 Apr;21(4):387.e1-4. doi: 10.1016/j.cmi.2014.11.010. Epub 2014 Nov 26.
Ref 3 A multicenter study of the clonal structure and resistance mechanism of KPC-producing Escherichia coli isolates in Israel. Clin Microbiol Infect. 2015 Mar;21(3):230-5. doi: 10.1016/j.cmi.2014.10.008. Epub 2014 Oct 29.
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