Peptide Information

General Information of This Peptide
Peptide ID
BTDP000185
Peptide Name
GPTX1 (Pro11Ala)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Mutant Sequence
DCLGFMRKCIADNDKCCRPNLVCSRTHKWCKYVF
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Sequence Length
34
Mass(Da)
4055
Sequence Removed Signal Peptide
DCLGFMRKCIADNDKCCRPNLVCSRTHKWCKYVF
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Disulfide Bond
2-17;9-23;16-30
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
170 nM
 . . [1]
 Target Info    Nav1.5 IC50
>5 μM
 . . [2]
 Target Info    Nav1.4 IC50
3.0 ± 0.5 μM
 . . [3]
References
Ref 1 Quantitative analysis of thiolated ligand exchange on gold nanoparticles monitored by 1H NMR spectroscopy. Anal Chem. 2015 Mar 3;87(5):2771-8. doi: 10.1021/ac504081k. Epub 2015 Feb 6.
Ref 2 Paradoxical immune reconstitution inflammatory syndrome associated with cryptococcal meningitis in China: a 5-year retrospective cohort study. Clin Microbiol Infect. 2015 Apr;21(4):379.e11-4. doi: 10.1016/j.cmi.2014.11.011. Epub 2014 Nov 20.
Ref 3 IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals. Clin Microbiol Infect. 2015 Mar;21(3):289.e1-4. doi: 10.1016/j.cmi.2014.10.012. Epub 2014 Oct 29.
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