Peptide Information

General Information of This Peptide
Peptide ID
BTDP000180
Peptide Name
GPTX1 (Phe5 Val)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Mutant Sequence
DCLGVMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Sequence Length
34
Mass(Da)
4033
Sequence Removed Signal Peptide
DCLGVMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Disulfide Bond
2-17;9-23;16-30
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
19 nM
 . . [1]
 Target Info    Nav1.5 IC50
>1 μM
 . . [1]
 Target Info    Nav1.4 IC50
4.1 μM
 . . [1]
References
Ref 1 Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel. J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19.
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