Peptide Information

General Information of This Peptide
Peptide ID
BTDP000162
Peptide Name
GPTX1 (Lys31Trp)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Mutant Sequence
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCWYVF
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Sequence Length
34
Mass(Da)
4139
Sequence Removed Signal Peptide
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCWYVF
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Disulfide Bond
2-17;9-23;16-30
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
>4.9 μM
 . . [1]
 Target Info    Nav1.4 IC50
>5 μM
 . . [1]
 Target Info    Nav1.5 IC50
>5 μM
 . . [1]
References
Ref 1 Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1. J Med Chem. 2016 Mar 24;59(6):2704-17. doi: 10.1021/acs.jmedchem.5b01947. Epub 2016 Mar 10.
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