Peptide Information

General Information of This Peptide
Peptide ID
BTDP000123
Peptide Name
GPTX1 (Asp1Ala)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Mutant Sequence
ACLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Sequence Length
34
Mass(Da)
4037
Sequence Removed Signal Peptide
ACLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Disulfide Bond
2-17;9-23;16-30
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
100 nM
 . . [1]
 Target Info    Nav1.5 IC50
>5 μM
 . . [2]
 Target Info    Nav1.4 IC50
1.8 ± 0.1 μM
 . . [3]
References
Ref 1 Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel. J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19.
Ref 2 Collateral damage from oral ciprofloxacin versus nitrofurantoin in outpatients with urinary tract infections: a culture-free analysis of gut microbiota. Clin Microbiol Infect. 2015 Apr;21(4):344.e1-11. doi: 10.1016/j.cmi.2014.11.016. Epub 2014 Nov 25.
Ref 3 Rapidly growing mycobacteria in Singapore, 2006-2011. Clin Microbiol Infect. 2015 Mar;21(3):236-41. doi: 10.1016/j.cmi.2014.10.018. Epub 2014 Nov 4.
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