Target Information

General Information of This Target
Target ID
BTDT10103
Target Name
Nicotinic acetylcholine receptor (nAChR) alpha-1-beta-1-gamma-delta
Target Bioclass
Receptor
Taxonomy ID
10116
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Alpha-conotoxin CIA IC50
5.7 nM
 [1], [2]
 Toxin Info    Neurotoxin Oh9-1 IC50
5.6 μM
 [3], [4]
References
Ref 1 Evolution of Conus peptide genes: duplication and positive selection in the A-superfamily. J Mol Evol. 2010 Feb;70(2):190-202. doi: 10.1007/s00239-010-9321-7. Epub 2010 Feb 9.
Ref 2 Synthesis, Structure and Biological Activity of CIA and CIB, Two -Conotoxins from the Predation-Evoked Venom of Conus catus. Toxins (Basel). 2018 Jun 1;10(6):222. doi: 10.3390/toxins10060222.
Ref 3 Purification and characterization of a neurotoxin from the venom of Ophiophagus hannah (king cobra). Biochem Biophys Res Commun. 2002 Jun 14;294(3):574-8. doi: 10.1016/S0006-291X(02)00518-1.
Ref 4 A Distinct Functional Site in -Neurotoxins: Novel Antagonists of Nicotinic Acetylcholine Receptors from Snake Venom. ACS Chem Biol. 2015 Dec 18;10(12):2805-15. doi: 10.1021/acschembio.5b00492. Epub 2015 Oct 15.
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