General Information of This Target
Target ID
BTDT10057
Target Name
Gamma-aminobutyric acid receptor subunit beta-3
Target Bioclass
Receptor
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Alpha-bungarotoxin Dissociation constant
50 nM
[1- 23]
References
Ref 1 Genetic characterization of the mRNAs encoding alpha-bungarotoxin: isoforms and RNA editing in Bungarus multicinctus gland cells. Nucleic Acids Res. 1998 Dec 15;26(24):5624-9. doi: 10.1093/nar/26.24.5624.
Ref 2 Genetic organization of alpha-bungarotoxins from Bungarus multicinctus (Taiwan banded krait): evidence showing that the production of alpha-bungarotoxin isotoxins is not derived from edited mRNAs. Nucleic Acids Res. 1999 Oct 15;27(20):3970-5. doi: 10.1093/nar/27.20.3970.
Ref 3 Purification, properties and amino acid sequence of -bungarotoxin from the venom of Bungarus multicinctus. Hoppe Seylers Z Physiol Chem. 1972 Feb;353(2):243-62. doi: 10.1515/bchm2.1972.353.1.243.
Ref 4 Primary structure of alpha-bungarotoxin. Six amino acid residues differ from the previously reported sequence. FEBS Lett. 1987 Sep 28;222(1):79-82. doi: 10.1016/0014-5793(87)80195-3.
Ref 5 Isolation of antigenically reactive peptide fragments and localization of antigenic regions of alpha-bungarotoxin. Biochem Biophys Res Commun. 1988 Sep 15;155(2):870-6. doi: 10.1016/s0006-291x(88)80576-x.
Ref 6 cDNA sequence analysis and expression of alpha-bungarotoxin from Taiwan banded krait (Bungarus multicinctus). Biochem Biophys Res Commun. 1995 Nov 22;216(3):1088-94. doi: 10.1006/bbrc.1995.2732.
Ref 7 Structural studies of alpha-bungarotoxin. 3. Corrections in the primary sequence and X-ray structure and characterization of an isotoxic alpha-bungarotoxin. Biochemistry. 1988 Apr 19;27(8):2775-81. doi: 10.1021/bi00408a018.
Ref 8 Neutralizing monoclonal antibody specific for alpha-bungarotoxin: preparation and characterization of the antibody, and localization of antigenic region of alpha-bungarotoxin. FEBS Lett. 1989 Aug 28;254(1-2):106-10. doi: 10.1016/0014-5793(89)81018-x.
Ref 9 Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor. J Biol Chem. 1997 Sep 26;272(39):24279-86. doi: 10.1074/jbc.272.39.24279.
Ref 10 Effects of alpha-erabutoxin, alpha-bungarotoxin, alpha-cobratoxin and fasciculin on the nicotine-evoked release of dopamine in the rat striatum in vivo. Neurochem Int. 1998 Oct;33(4):307-12. doi: 10.1016/s0197-0186(98)00033-3.
Ref 11 The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5149-54. doi: 10.1073/pnas.0600847103. Epub 2006 Mar 20.
Ref 12 Neurotoxins from snake venoms and -conotoxin ImI inhibit functionally active ionotropic -aminobutyric acid (GABA) receptors. J Biol Chem. 2015 Sep 11;290(37):22747-58. doi: 10.1074/jbc.M115.648824. Epub 2015 Jul 28.
Ref 13 Snake neurotoxin -bungarotoxin is an antagonist at native GABA(A) receptors. Neuropharmacology. 2015 Jun;93:28-40. doi: 10.1016/j.neuropharm.2015.01.001. Epub 2015 Jan 26.
Ref 14 The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor. Protein Eng. 1986 Oct-Nov;1(1):37-46. doi: 10.1093/protein/1.1.37.
Ref 15 Structural studies of alpha-bungarotoxin. 1. Sequence-specific 1H NMR resonance assignments. Biochemistry. 1988 Apr 19;27(8):2763-71. doi: 10.1021/bi00408a016.
Ref 16 Structural studies of alpha-bungarotoxin. 2. 1H NMR assignments via an improved relayed coherence transfer nuclear overhauser enhancement experiment. Biochemistry. 1988 Apr 19;27(8):2772-5. doi: 10.1021/bi00408a017.
Ref 17 NMR solution structure of an alpha-bungarotoxin/nicotinic receptor peptide complex. Biochemistry. 1993 Nov 23;32(46):12290-8. doi: 10.1021/bi00097a004.
Ref 18 Three-dimensional solution structure of the complex of alpha-bungarotoxin with a library-derived peptide. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6059-64. doi: 10.1073/pnas.94.12.6059.
Ref 19 The solution structure of the complex formed between alpha-bungarotoxin and an 18-mer cognate peptide derived from the alpha 1 subunit of the nicotinic acetylcholine receptor from Torpedo californica. J Biol Chem. 2001 Jun 22;276(25):22930-40. doi: 10.1074/jbc.M102300200. Epub 2001 Apr 18.
Ref 20 A beta -hairpin structure in a 13-mer peptide that binds alpha -bungarotoxin with high affinity and neutralizes its toxicity. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6629-34. doi: 10.1073/pnas.111164298. Epub 2001 May 29.
Ref 21 NMR structure of alpha-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor. Biochemistry. 2002 Feb 5;41(5):1457-63. doi: 10.1021/bi011012f.
Ref 22 NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor. J Biol Chem. 2002 Apr 5;277(14):12406-17. doi: 10.1074/jbc.M110320200. Epub 2002 Jan 14.
Ref 23 The mechanism for acetylcholine receptor inhibition by alpha-neurotoxins and species-specific resistance to alpha-bungarotoxin revealed by NMR. Neuron. 2002 Jul 18;35(2):319-32. doi: 10.1016/s0896-6273(02)00773-0.
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