Target Information

General Information of This Target
Target ID
BTDT10043
Target Name
Elastase
Target Bioclass
Enzyme
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Venom peptide SjAPI Inhibition constant
3.7 μM
 [1]
 Toxin Info    Kunitz-type serine protease inhibitor taicotoxin IC50
201 nM
 [2- 7]
References
Ref 1 SjAPI, the first functionally characterized Ascaris-type protease inhibitor from animal venoms. PLoS One. 2013;8(3):e57529. doi: 10.1371/journal.pone.0057529. Epub 2013 Mar 22.
Ref 2 Common evolution of waprin and kunitz-like toxin families in Australian venomous snakes. Cell Mol Life Sci. 2008 Dec;65(24):4039-54. doi: 10.1007/s00018-008-8573-5.
Ref 3 Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels. Toxicon. 1992 Nov;30(11):1343-64. doi: 10.1016/0041-0101(92)90511-3.
Ref 4 Identification and characterisation of Kunitz-type plasma kallikrein inhibitors unique to Oxyuranus sp. snake venoms. Biochimie. 2012 Feb;94(2):365-73. doi: 10.1016/j.biochi.2011.08.003. Epub 2011 Aug 11.
Ref 5 Effect of TaiCatoxin (TCX) on the electrophysiological, mechanical and biochemical characteristics of spontaneously beating ventricular cardiomyocytes. Mol Cell Biochem. 1996 Jul-Aug;160-161:61-6. doi: 10.1007/BF00240032.
Ref 6 A novel small conductance Ca2+-activated K+ channel blocker from Oxyuranus scutellatus taipan venom. Re-evaluation of taicatoxin as a selective Ca2+ channel probe. J Biol Chem. 1997 Aug 8;272(32):19925-30. doi: 10.1074/jbc.272.32.19925.
Ref 7 Taicatoxin inhibits the calcium-dependent slow motility of mammalian outer hair cells. Hear Res. 2005 May;203(1-2):172-9. doi: 10.1016/j.heares.2004.12.003.
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