Peptide Information

General Information of This Peptide
Peptide ID
BTDP008418
Peptide Name
Kunitz-type serine protease inhibitor taicotoxin
Symonym
Taicatoxin, serine protease inhibitor component; Venom protease inhibitor 1; Venom protease inhibitor 2
Species
Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan)
Uniprot Name
VKT_OXYSC
Alphafold ID
B7S4N9
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: B7S4N9
Sequence
MSSGGLLLLLGLLTLWEVLTPVSSKDRPKFCHLPPKPGPCRAAIPRFYYNPHSKQCEKFI
YGGCHGNANSFKTPDECNYTCLGVSLPK
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Sequence Length
88
Mass (Da)
9711
Signal Sequence
MSSGGLLLLLGLLTLWEALTPVSS
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Sequence Removed Signal Peptide
KDRPKFCHLPPKPGPCRAAIPRFYYNPHSKQCEKFIYGGCHGNANSFKTPDECNYTCLGV
SLPK
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Disulfide Bond
31-81;40-64;56-77
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Oxyuranus
Species: Oxyuranus scutellatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa2 . . . . [1- 6]
 Target Info    plasma kallikrein IC50
0.057 nM
 .
Monomer
 [1- 6]
 Target Info    tissue kallikrein IC50
0.23 nM
 .
Monomer
 [1- 6]
 Target Info    trypsin IC50
0.31 nM
 .
Monomer
 [1- 6]
 Target Info    plasmin IC50
6.1 nM
 .
Monomer
 [1- 6]
 Target Info    elastase IC50
201 nM
 .
Monomer
 [1- 6]
 Target Info    factor Xa (F10) IC50
871 nM
 .
Monomer
 [1- 6]
 Target Info    alpha-factor XIIa IC50
2.38 μM
 .
Monomer
 [1- 6]
References
Ref 1 Common evolution of waprin and kunitz-like toxin families in Australian venomous snakes. Cell Mol Life Sci. 2008 Dec;65(24):4039-54. doi: 10.1007/s00018-008-8573-5.
Ref 2 Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels. Toxicon. 1992 Nov;30(11):1343-64. doi: 10.1016/0041-0101(92)90511-3.
Ref 3 Identification and characterisation of Kunitz-type plasma kallikrein inhibitors unique to Oxyuranus sp. snake venoms. Biochimie. 2012 Feb;94(2):365-73. doi: 10.1016/j.biochi.2011.08.003. Epub 2011 Aug 11.
Ref 4 Effect of TaiCatoxin (TCX) on the electrophysiological, mechanical and biochemical characteristics of spontaneously beating ventricular cardiomyocytes. Mol Cell Biochem. 1996 Jul-Aug;160-161:61-6. doi: 10.1007/BF00240032.
Ref 5 A novel small conductance Ca2+-activated K+ channel blocker from Oxyuranus scutellatus taipan venom. Re-evaluation of taicatoxin as a selective Ca2+ channel probe. J Biol Chem. 1997 Aug 8;272(32):19925-30. doi: 10.1074/jbc.272.32.19925.
Ref 6 Taicatoxin inhibits the calcium-dependent slow motility of mammalian outer hair cells. Hear Res. 2005 May;203(1-2):172-9. doi: 10.1016/j.heares.2004.12.003.
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