Target Information

General Information of This Target
Target ID
BTDT10019
Target Name
Alpha-2B adrenergic receptor
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Rho-elapitoxin-Da1b Inhibition constant
73 nM
 [1], [2], [3], [4]
References
Ref 1 Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the 2-adrenoceptors. Br J Pharmacol. 2010 Nov;161(6):1361-74. doi: 10.1111/j.1476-5381.2010.00966.x.
Ref 2 G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors. Toxicon. 2012 Mar 15;59(4):487-96. doi: 10.1016/j.toxicon.2011.03.009. Epub 2011 Mar 22.
Ref 3 Polypharmacology profiles and phylogenetic analysis of three-finger toxins from mamba venom: case of aminergic toxins. Biochimie. 2014 Aug;103:109-17. doi: 10.1016/j.biochi.2014.04.009. Epub 2014 May 1.
Ref 4 Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins. Sci Rep. 2017 Jun 2;7(1):2701. doi: 10.1038/s41598-017-02953-0.
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