Peptide Information

General Information of This Peptide
Peptide ID
BTDP006820
Peptide Name
Rho-elapitoxin-Da1b
Symonym
Rho-Da1b; Rho-EPTX-Da1b
Species
Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Uniprot Name
3SI1B_DENAN
Alphafold ID
P86419
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P86419
Sequence
LTCVTKDTIFGITTQNCPAGQNLCFIRRHYINHRYTEITRGCTATCPKPTNVRETIHCCN
TDKCNE
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Sequence Length
66
Mass (Da)
7521
Sequence Removed Signal Peptide
LTCVTKDTIFGITTQNCPAGQNLCFIRRHYINHRYTEITRGCTATCPKPTNVRETIHCCN
TDKCNE
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Disulfide Bond
3-24;17-42;46-58;59-64
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis angusticeps
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    ADRA2A Inhibition constant
14 nM
 . . [1], [2], [3], [4]
 Target Info    ADRA2C Inhibition constant
38 nM
 . . [1], [2], [3], [4]
 Target Info    ADRA2B Inhibition constant
73 nM
 . . [1], [2], [3], [4]
References
Ref 1 Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the 2-adrenoceptors. Br J Pharmacol. 2010 Nov;161(6):1361-74. doi: 10.1111/j.1476-5381.2010.00966.x.
Ref 2 G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors. Toxicon. 2012 Mar 15;59(4):487-96. doi: 10.1016/j.toxicon.2011.03.009. Epub 2011 Mar 22.
Ref 3 Polypharmacology profiles and phylogenetic analysis of three-finger toxins from mamba venom: case of aminergic toxins. Biochimie. 2014 Aug;103:109-17. doi: 10.1016/j.biochi.2014.04.009. Epub 2014 May 1.
Ref 4 Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins. Sci Rep. 2017 Jun 2;7(1):2701. doi: 10.1038/s41598-017-02953-0.
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