Target Information

General Information of This Target
Target ID
BTDT10001
Target Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Target Bioclass
Enzyme
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Lipolysis-activating peptide 1-beta chain Inhibition rate
32 %
 [1]
 Toxin Info    Lipolysis-activating peptide 1-beta chain Inhibition rate
32 %
 [1]
 Toxin Info    Lipolysis-activating peptide 1-beta chain Inhibition rate
32 %
 [2]
 Toxin Info    HMG-CoA reductase inhibitor bumarsin Inhibition rate
32 %
 [3], [4], [5], [6]
References
Ref 1 Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components. BMC Genomics. 2010 Jul 28;11:452. doi: 10.1186/1471-2164-11-452.
Ref 2 Isolation and molecular characterization of LVP1 lipolysis activating peptide from scorpion Buthus occitanus tunetanus. Biochim Biophys Acta. 2005 Feb 14;1747(1):47-56. doi: 10.1016/j.bbapap.2004.09.020. Epub 2004 Oct 27.
Ref 3 Charaterization of bumarsin, a 3-hydroxy-3-methylglutaryl-coenzyme reductase inhibitor from Mesobuthus martensii Karsch venom. Toxicon. 2012 Sep 1;60(3):272-9. doi: 10.1016/j.toxicon.2012.04.352. Epub 2012 May 7.
Ref 4 Precursors of three unique cysteine-rich peptides from the scorpion Buthus martensii Karsch. Comp Biochem Physiol B Biochem Mol Biol. 2002 Apr;131(4):749-56. doi: 10.1016/s1096-4959(02)00020-9.
Ref 5 Molecular dissection of venom from Chinese scorpion Mesobuthus martensii: identification and characterization of four novel disulfide-bridged venom peptides. Peptides. 2006 Jul;27(7):1745-54. doi: 10.1016/j.peptides.2006.01.012. Epub 2006 Mar 2.
Ref 6 Molecular characterization of a new scorpion venom lipolysis activating peptide: Evidence for disulfide bridge-mediated functional switch of peptides. FEBS Lett. 2006 Dec 22;580(30):6825-36. doi: 10.1016/j.febslet.2006.11.040. Epub 2006 Nov 27.
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