Peptide Information

General Information of This Peptide
Peptide ID
BTDP007789
Peptide Name
HMG-CoA reductase inhibitor bumarsin
Symonym
JCH2; Lipolysis-activating peptide 1-beta chain; Neurotoxin KITx; Putative toxin BmKTXLP2
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
LV1B_MESMA
Alphafold ID
Q95P90
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: Q95P90
Sequence
MVKMQVIFIAFIAVIACSMVYGDSLSPWNEGDTYYGCQRQTDEFCNKICKLHLASGGSCQ
QPAPFVKLCTCQGIDYDNSFFFGALEKQCPKLRG
   Click to Show/Hide
Sequence Length
94
Mass (Da)
10477
Signal Sequence
MVKMQVIFIAFIAVIACSMVYG
   Click to Show/Hide
Sequence Removed Signal Peptide
DSLSPWNEGDTYYGCQRQTDEFCNKICKLHLASGGSCQQPAPFVKLCTCQGIDYDNSFFF
GALEKQCPKLRG
   Click to Show/Hide
Disulfide Bond
37-59;45-69;49-71;89
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    HMG-CoA reductase (HMGCR) Inhibition rate
32 %
0.6 μM
 . [1], [2], [3], [4]
References
Ref 1 Charaterization of bumarsin, a 3-hydroxy-3-methylglutaryl-coenzyme reductase inhibitor from Mesobuthus martensii Karsch venom. Toxicon. 2012 Sep 1;60(3):272-9. doi: 10.1016/j.toxicon.2012.04.352. Epub 2012 May 7.
Ref 2 Precursors of three unique cysteine-rich peptides from the scorpion Buthus martensii Karsch. Comp Biochem Physiol B Biochem Mol Biol. 2002 Apr;131(4):749-56. doi: 10.1016/s1096-4959(02)00020-9.
Ref 3 Molecular dissection of venom from Chinese scorpion Mesobuthus martensii: identification and characterization of four novel disulfide-bridged venom peptides. Peptides. 2006 Jul;27(7):1745-54. doi: 10.1016/j.peptides.2006.01.012. Epub 2006 Mar 2.
Ref 4 Molecular characterization of a new scorpion venom lipolysis activating peptide: Evidence for disulfide bridge-mediated functional switch of peptides. FEBS Lett. 2006 Dec 22;580(30):6825-36. doi: 10.1016/j.febslet.2006.11.040. Epub 2006 Nov 27.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.