Target Information
General Information of This Target
| Target ID |
BTDT00235
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| Target Name |
Gamma-aminobutyric acid type B receptor subunit 1 (Gabbr1);Gamma-aminobutyric acid type B receptor subunit 2 (Gabbr2)
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| Target Bioclass |
Transporter and channel
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| Uniprot ID | ||||||
| 3D Structure | ||||||
| Gene Name |
Gabbr1;Gabbr2
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| Gene ID | ||||||
| Synonym 2 |
G-protein coupled receptor 51
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| Sequence 1 |
MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDY
EIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPA LDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGG WPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKII LMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLF EKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARI IVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEG HITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALAL NKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQ LQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSL GIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPF VCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMD VLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSD VQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIY NVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSET QDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPT PPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK Click to Show/Hide
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| Sequence 2 |
MASPPSSGQPRPPPPPPPPARLLLPLLLSLLLWLAPGAWGWTRGAPRPPPSSPPLSIMGL
MPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAI KYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNA VNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVK KLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEPAWWEQVHVEANSSR CLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQFEREYNSKRSGVGPSKFHGYAYDG IWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQVVFRNGE RMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPL YSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDG SFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIV GGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVY AYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQF CIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVN QASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILSLG NFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHH AYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL Click to Show/Hide
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| Family1 |
the G-protein coupled receptor 3 family.
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| Family2 |
the G-protein coupled receptor 3 family
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| Function 1 |
Component of a heterodimeric G-protein coupled receptor for; GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1; seems to bind agonists, while GABBR2 mediates coupling to G proteins;Ligand binding causes a conformation; change that triggers signaling via guanine nucleotide-binding proteins; (G proteins) and modulates the activity of down-stream effectors, such; as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates; phospholipase A2, activates potassium channels, inactivates voltage-; dependent calcium-channels and modulates inositol phospholipid; hydrolysis. Calcium is required; for high affinity binding to GABA Plays a critical; role in the fine-tuning of inhibitory synaptic transmission; Pre-synaptic GABA receptor inhibits neurotransmitter; release by down-regulating high-voltage activated calcium channels;whereas postsynaptic GABA receptor decreases neuronal excitability by; activating a prominent inwardly rectifying potassium (Kir) conductance; that underlies the late inhibitory postsynaptic potentials. Not only implicated; in synaptic inhibition but also in hippocampal long-term potentiation;slow wave sleep, muscle relaxation and antinociception .
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| Function 2 |
Component of a heterodimeric G-protein coupled receptor for; GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1; seems to bind agonists, while GABBR2 mediates coupling to G proteins;Ligand binding causes a conformation; change that triggers signaling via guanine nucleotide-binding proteins; (G proteins) and modulates the activity of down-stream effectors, such; as adenylate cyclase. Signaling inhibits; adenylate cyclase, stimulates phospholipase A2, activates potassium; channels, inactivates voltage-dependent calcium-channels and modulates; inositol phospholipid hydrolysis. Plays a critical; role in the fine-tuning of inhibitory synaptic transmission; ( , , ). Pre-synaptic GABA; receptor inhibits neurotransmitter release by down-regulating high-; voltage activated calcium channels, whereas postsynaptic GABA receptor; decreases neuronal excitability by activating a prominent inwardly; rectifying potassium (Kir) conductance that underlies the late; inhibitory postsynaptic potentials .; Not only implicated in synaptic inhibition but also in hippocampal; long-term potentiation, slow wave sleep, muscle relaxation and; antinociception .
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| TCDB ID | ||||||
| Click to Show/Hide the Complete Species Lineage | ||||||
Toxin Information Related to This Target
| Toxin Name | Activity Data Type | Activity Data | Reference |
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| Toxin Info Alpha-conotoxin-like Kn1.2 | Inhibition rate |
13 %
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[1], [2] |
References
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