Peptide Information

General Information of This Peptide
Peptide ID
BTDP003364
Peptide Name
Alpha-conotoxin-like Kn1.2
Species
Conus kinoshitai (Kinoshita's cone)
Uniprot Name
CA12_CONKI
Alphafold ID
D4HRK7
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: D4HRK7
Sequence
ESDGAHAKARADKPARSATNRQPGCCNNPACVKHRCG
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Sequence Length
37
Mass (Da)
3878
Sequence Removed Signal Peptide
ESDGAHAKARADKPARSATNRQPGCCNNPACVKHRCG
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Disulfide Bond
25-31;26-36
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus kinoshitai
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    GABBR1 and/or GABBR2 Inhibition rate
13 %
1 μM
 . [1], [2]
References
Ref 1 Evolution of Conus peptide genes: duplication and positive selection in the A-superfamily. J Mol Evol. 2010 Feb;70(2):190-202. doi: 10.1007/s00239-010-9321-7. Epub 2010 Feb 9.
Ref 2 Structure-Activity Studies of Cysteine-Rich -Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew Chem Int Ed Engl. 2016 Apr 4;55(15):4692-6. doi: 10.1002/anie.201600297. Epub 2016 Mar 7.
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