Target Information

General Information of This Target
Target ID
BTDT00230
Target Name
B1 bradykinin receptor (Bdkrb1);B2 bradykinin receptor (Bdkrb2)
Target Bioclass
Receptor
Uniprot ID
P97583 ; P25023
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
?
Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
Bdkrb1;Bdkrb2
Gene ID
81509 ; 25245
Synonym 1
Kinin B1 receptor
Synonym 2
.;.
Sequence 1
MASEVLLELQPSNRSLQAPANITSCESALEDWDLLYRVLPGFVITICFFGLLGNLLVLSF
FLLPWRQWWWQQRQRQQRLTIAEIYLANLAASDLVFVLGLPFWAENIGNRFNWPFGTDLC
RVVSGVIKANLFVSIFLVVAISQDRYRLLVYPMTSWGYRRRRQAQATCLLIWVAGGLLSI
PTFLLRSVKVVPDLNVSACILLFPHEAWHFARMVELNVLGFLLPVTAIIFFNYHILASLR
GQKEASRTRCGGPKGSKTTGLILTLVASFLVCWCPYHFFAFLDFLVQVRVIQDCSWKEIT
DLGLQLANFFAFVNSCLNPLIYVFAGRLLKTRVLGTL

    Click to Show/Hide
Sequence 2
MDTRSSLCPKTQAVVAVFWGPGCHLSTCIEMFNITTQALGSAHNGTFSEVNCPDTEWWSW
LNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAI
TIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAK
LYSLVIWSCTLLLSSPMLVFRTMKDYREEGHNVTACVIVYPSRSWEVFTNMLLNLVGFLL
PLSIITFCTVRIMQVLRNNEMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTL
LRLGVLSGCWNERAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGG
CMGESVQMENSMGTLRTSISVDRQIHKLQDWAGNKQ

    Click to Show/Hide
Family1
the G-protein coupled receptor 1 family
Family2
the G-protein coupled receptor 1 family
Function 1
This is a receptor for bradykinin. Could be a factor in; chronic pain and inflammation.

    Click to Show/Hide
Function 2
Receptor for bradykinin. It is associated with G proteins; that activate a phosphatidylinositol-calcium second messenger system.

    Click to Show/Hide
Taxonomy ID
10116
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
1.1 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
1.1 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
1.2 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
1.2 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
1.5 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
1.5 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
3.5 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
3.5 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
3.9 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
3.9 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
4.6 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
4.6 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
10.8 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
10.8 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
16.8 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
16.8 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
56.7 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
56.7 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
60.3 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
60.3 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
205 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
205 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
223 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
223 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
356 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
356 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
588 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
588 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
645 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
645 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
895 nM
 [1]
 Toxin Info    [Thr6]-bradykinyl-Val,Asp Effective concentration 50
895 nM
 [1]
References
Ref 1 Bradykinin-related peptides (BRPs) from skin secretions of three genera of phyllomedusine leaf frogs and their comparative pharmacological effects on mammalian smooth muscles. Peptides. 2014 Feb;52:122-33. doi: 10.1016/j.peptides.2013.12.013. Epub 2014 Jan 3.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.