Target Information

General Information of This Target
Target ID
BTDT00173
Target Name
Sodium channel protein
Target Bioclass
Transporter and channel
Uniprot ID
Q93135
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
AWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLR
DVIILTMFSLSVLALMGLQIYMGVLTQKCIKNFPINGSWGELNDENWHAFCSNNTNWYFP
EGAPEVPLCGNSSGAGTCPPVYTCLQGFGENPNYGYTSFDTFGWAFLSAFRLMTQDYWEN
LYQLVLRSAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEALRE
AEEAALAKEAKKLRQADKLAAQELAAAQELAGANLAKSPSGSSSRSYELFINQKDGNNDN
KRENMSIRSEGGDSISEHKGRVGANGTAIRKVSAATLSLPGSPFNHRRGSQGSHHFTIRN
GRGRFVGPPGGDRKPLVLSTYLDAQEHLPYADDSNAVTPMSEENGAIVVPVYYASLGSRH
SSYTSHASRISYTSHGDLLGAGNKSQTKINQLRVRSVRNNPSQVPNSTPYMNASADSDDG
AVKAKHTDNPFIEQMQQTTIVDMNDVMVLNDIIEQAAGQQSRASEHGDEDDEGPTVKEKV
LAICMRGIDIFCVWDCCWLWLKFQEYVALLVFDPFVELFITLCIVVNTLFMALDHHDMNK
DMDKALKSGNYFFTATFAIEATLKLIAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQG
LSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTVGALGNLTFVLCIIIFIFAVMGMQLFGK
NYYDNVERFPDGDMPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLVGDWSCIPFFLATV
VIGNLVVLNLFLALLLSNFGSSNLSAPTADNETNKIAEAFERFSRFFNWIKRSALNVAKM
LRAKLTNQISDQTPDAHERDTDLDLTAAEILADGIVYRDKKSPKEQTQLEVAIGDGMEFT
IHGDLKNKLKKDKLMMNSTKVIGNSLNHKDNRIESGDYLHNRQDEDTLSTGSYGSHKNRP
YKDDSHKGSAETMDGEEKKDASKEDLDQEGEGEEDGEGEGPLEEDMVLDAGTEDVMMSEY
PADCCPDHCYKRFPFLAGDEDSPFWQGWGNLRLKTFQLIENKYFETAVITMILLSSLALA
LEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFKKYFTNAWCWLDFIIVMVSL
INFVATLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI
FWLIFAIMGVQLFAGKYHKCVDSNSTTLSHEIIPDRNACIAENYTWENSPMNFDHVGKAY
LCLFQVATFKGWIQIMNDAIDSRELHKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVI
IDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPKWRPQAIVFEICTDK
KFDMIIMLFIGFNMLTMTLDHYQQSKQFSDVLDYLNMIFIVIFSSECLMKIFALRYHYFK
EPWNLFDFVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLF
ALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVRDKGGLDDVYNFKTFGQSMILLFQMS
TSAGWDGVLDGIMNEEDCNKPNSEIGYPGDCGSATVGIAFLLSYLVISFLIVINMYIAVI
LENYSQATEDVQEGLTDDDYDMYYEIWQQFDPDGTQYIRYDQLSDFLDVLEPPLQIHKPN
KYKIVSMDM

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Family
the sodium channel (TC 1.A.1.10) family
Function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.

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Taxonomy ID
6973
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Blattodea
Family: Blattellidae
Genus: Blattella
Species: Blattella germanica
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    GAMMA-ctenitoxin-Pb1a Increase rate
105 %
 [1]
 Toxin Info    GAMMA-ctenitoxin-Pb1a Effective concentration 50
212.5 nM
 [1]
References
Ref 1 Partial Characterization of Venom from the Colombian Spider Phoneutria Boliviensis (Aranae:Ctenidae). Toxins (Basel). 2015 Jul 31;7(8):2872-87. doi: 10.3390/toxins7082872.
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