Target Information

General Information of This Target
Target ID
BTDT00044
Target Name
Chymotrypsin-like elastase family member 3B (CELA3B)
Target Bioclass
Enzyme
Uniprot ID
P08861
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
CELA3B
Gene ID
23436
Synonym
ELA3B; Elastase IIIB; Elastase-3B; Protease E
Sequence
MMLRLLSSLLLVAVASGYGPPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTCGG
SLIAPDWVVTAGHCISSSRTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCVAC
GNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQEALL
PVVDYEHCSRWNWWGSSVKKTMVCAGGDIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVS
AFGCNTRRKPTVFTRVSAFIDWIEETIASH

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Family
the peptidase S1 family
Function
Efficient protease with alanine specificity but only little elastolytic activity.

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Taxonomy ID
9606
EC Number
3.4.21.70
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Secapin Inhibition constant
125.62 nM
 [1]
 Toxin Info    Secapin IC50
94.7 nM
 [1]
References
Ref 1 Secapin, a bee venom peptide, exhibits anti-fibrinolytic, anti-elastolytic, and anti-microbial activities. Dev Comp Immunol. 2016 Oct;63:27-35. doi: 10.1016/j.dci.2016.05.011. Epub 2016 May 18.
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