Peptide Information

General Information of This Peptide
Peptide ID
BTDP008951
Peptide Name
Kappa-hefutoxin 2 (C1H,Y2A,R3C,N4Y,C5R,W6N,R7C,E8W,G9R,N10E,D11G,E12N,E13D,T14E,C15E,K16T,E17C,R18K,C19E)
Symonym
Kappa-hefutoxin 2 (C1H,Y2A,R3C,N4Y,C5R,W6N,R7C,E8W,G9R,N10E,D11G,E12N,E13D,T14E,C15E,K16T,E17C,R18K,C19E)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
CYRNCWREGNDEETCKERC
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Mutant Sequence
HACYRNCWREGNDEETCKERC
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Sequence Length
21
Mass(Da)
2598
Sequence Removed Signal Peptide
HACYRNCWREGNDEETCKERC
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv10 Inhibition rate
10.2 %
40 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate
13.6 %
40 μM
Blocker
 [2]
References
Ref 1 Expanding the pharmacological profile of -hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel K(v)10.1. Peptides. 2017 Dec;98:43-50. doi: 10.1016/j.peptides.2016.08.008. Epub 2016 Aug 28.
Ref 2 Synthesis and characterization of amino acid deletion analogs of -hefutoxin 1, a scorpion toxin on potassium channels. Toxicon. 2013 Sep;71:25-30. doi: 10.1016/j.toxicon.2013.05.010. Epub 2013 May 29.
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