Peptide Information

General Information of This Peptide
Peptide ID
BTDP008950
Peptide Name
Kappa-hefutoxin 2 (C1A,Y2C,R3Y,N4R,C5N,W6C,R7W,E8R,G9E,N10G,D11N,E12D,T14E,C15T,K16C,E17K,R18E,C19R)
Symonym
Kappa-hefutoxin 2 (C1A,Y2C,R3Y,N4R,C5N,W6C,R7W,E8R,G9E,N10G,D11N,E12D,T14E,C15T,K16C,E17K,R18E,C19R)
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
?
Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
CYRNCWREGNDEETCKERC
   Click to Show/Hide
Mutant Sequence
ACYRNCWREGNDEETCKERC
   Click to Show/Hide
Sequence Length
20
Mass(Da)
2461
Sequence Removed Signal Peptide
ACYRNCWREGNDEETCKERC
   Click to Show/Hide
Disulfide Bond
2-16;6-20
        Click to Show/Hide the Complete Species Lineage
N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.6 Inhibition rate
8.8 %
40 μM
Blocker
 [1]
 Target Info    Kv10 Inhibition rate
14.1 %
40 μM
Blocker
 [2]
References
Ref 1 Synthesis and characterization of amino acid deletion analogs of -hefutoxin 1, a scorpion toxin on potassium channels. Toxicon. 2013 Sep;71:25-30. doi: 10.1016/j.toxicon.2013.05.010. Epub 2013 May 29.
Ref 2 Expanding the pharmacological profile of -hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel K(v)10.1. Peptides. 2017 Dec;98:43-50. doi: 10.1016/j.peptides.2016.08.008. Epub 2016 Aug 28.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.