Peptide Information

General Information of This Peptide
Peptide ID
BTDP008923
Peptide Name
AgTx2
Symonym
AgTx2
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
GVPINVSCTGSPQCIKPCKDAGMRFGKCMNRKCHCTPK
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Sequence Length
38
Mass (Da)
4091
Sequence Removed Signal Peptide
GVPINVSCTGSPQCIKPCKDAGMRFGKCMNRKCHCTPK
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KcsA-Kv1.6 Dissociation constant
1 nM
 .
Blocker
 [1]
 Target Info    KcsA-Kv1.1 Dissociation constant
3.4 nM
 .
Blocker
 [2]
 Target Info    KcsA-Kv1.3 Dissociation constant
3.9 nM
 .
Blocker
 [3]
 Target Info    KcsA-Kv1.1 Inhibition rate .
100 nM
Blocker
 [3]
 Target Info    KcsA-Kv1.6 Inhibition rate .
100 nM
Blocker
 [3]
References
Ref 1 Complexes of Peptide Blockers with Kv1.6 Pore Domain: Molecular Modeling and Studies with KcsA-Kv1.6 Channel. J Neuroimmune Pharmacol. 2017 Jun;12(2):260-276. doi: 10.1007/s11481-016-9710-9. Epub 2016 Sep 17.
Ref 2 Variability of Potassium Channel Blockers in Mesobuthus eupeus Scorpion Venom with Focus on Kv1.1: AN INTEGRATED TRANSCRIPTOMIC AND PROTEOMIC STUDY. J Biol Chem. 2015 May 8;290(19):12195-209. doi: 10.1074/jbc.M115.637611. Epub 2015 Mar 19.
Ref 3 Atto488-Agitoxin 2-A Fluorescent Ligand with Increased Selectivity for Kv1.3 Channel Binding Site. Bioengineering (Basel). 2022 Jul 1;9(7):295. doi: 10.3390/bioengineering9070295.
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