Peptide Information

General Information of This Peptide
Peptide ID
BTDP008779
Peptide Name
[K16,D20]- OsK1
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
GVIINVKCKISRQCLEPCKKAGMRFGKCMNGKCHCTPK
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Mutant Sequence
GVIINVKCKISRQCLKPCKDAGMRFGKCMNGKCHCTPK
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Sequence Length
38
Mass(Da)
4191
Sequence Removed Signal Peptide
GVIINVKCKISRQCLKPCKDAGMRFGKCMNGKCHCTPK
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Disulfide Bond
8-281;4-33;18-35
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 IC50
3 pM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
0.122 nM
 .
Blocker
 [1]
 Target Info    KCa3.1 IC50
228 nM
 .
Blocker
 [1]
 Target Info    KCa3.1 IC50
885 nM
 .
Blocker
 [1]
 Target Info    Kv1.7 IC50
1.5 μM
 .
Blocker
 [1]
References
Ref 1 K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 1;385(Pt 1):95-104. doi: 10.1042/BJ20041379.
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