Peptide Information

General Information of This Peptide
Peptide ID
BTDP008743
Peptide Name
MgTX
Symonym
MgTX
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH
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Sequence Length
39
Mass (Da)
4179
Sequence Removed Signal Peptide
TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv Dissociation constant
0.07 pM
 .
Blocker
 [1]
 Target Info    Kv1.3 Dissociation constant
0.19 pM
 .
Blocker
 [2]
 Target Info    Kv1.3 IC50
0.825 nM
 .
Blocker
 [3]
References
Ref 1 [125I]margatoxin, an extraordinarily high affinity ligand for voltage-gated potassium channels in mammalian brain. Biochemistry. 1995 Oct 17;34(41):13627-34. doi: 10.1021/bi00041a043.
Ref 2 Margatoxin binds to a homomultimer of K(V)1.3 channels in Jurkat cells. Comparison with K(V)1.3 expressed in CHO cells. Biochemistry. 1997 Mar 25;36(12):3737-44. doi: 10.1021/bi962351p.
Ref 3 Olfactory bulb-targeted quantum dot (QD) bioconjugate and Kv1.3 blocking peptide improve metabolic health in obese male mice. J Neurochem. 2021 Jun;157(6):1876-1896. doi: 10.1111/jnc.15200. Epub 2020 Oct 20.
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