Peptide Information

General Information of This Peptide
Peptide ID
BTDP008739
Peptide Name
PnCS2
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
CNCGGWGRWNCKC
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Mutant Sequence
DRRWARWNRK
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Sequence Length
10
Mass(Da)
1444
Sequence Removed Signal Peptide
DRRWARWNRK
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        Click to Show/Hide the Complete Species Lineage
N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 IC50
0.6 ± 0.2 μM
 . . [1]
 Target Info    Nav1.9 IC50
0.7 ± 0.2 μM
 . . [1]
 Target Info    Nav1.6 IC50
0.7 ± 0.2 μM
 . . [1]
 Target Info    Nav1.7 IC50
0.9 ± 0.1 μM
 . . [1]
 Target Info    Nav1.2 IC50
1.0 ± 0.1 μM
 . . [1]
 Target Info    Nav1.3 IC50
1.1 ± 0.2 μM
 . . [1]
 Target Info    Nav1.5 IC50
2.8 ± 0.6 μM
 . . [1]
 Target Info    Nav1.4 IC50
14.3 ± 1.4 μM
 . . [1]
 Target Info    Nav1.3 IC50
23 ± 1.6 μM
 . . [1]
References
Ref 1 Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors. FASEB J. 2019 Mar;33(3):3693-3703. doi: 10.1096/fj.201801909R. Epub 2018 Dec 3.
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