Peptide Information

General Information of This Peptide
Peptide ID
BTDP008731
Peptide Name
HWTX-IV
Species
Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
ECLEIFKACNPSNDQCCKSSKLVCSRKTRWCKYQI
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Sequence Length
35
Mass (Da)
4114
Sequence Removed Signal Peptide
ECLEIFKACNPSNDQCCKSSKLVCSRKTRWCKYQI
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Disulfide Bond
2-17;9-23;17-30
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Cyriopagopus
Species: Cyriopagopus schmidti
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.2 IC50
˜150 nM
 . . [1]
 Target Info    Nav1.7 IC50
17 nM
 . . [1]
 Target Info    Nav1.4 IC50
>10 μM
 . . [1]
 Target Info    Nav1.5 IC50
>10 μM
 . . [1]
 Target Info    Nav1.3 IC50
˜1.35 μM
 . . [1]
References
Ref 1 Potency optimization of Huwentoxin-IV on hNav1.7: a neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena. Peptides. 2013 Jun;44:40-6. doi: 10.1016/j.peptides.2013.03.011. Epub 2013 Mar 19.
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