Peptide Information

General Information of This Peptide
Peptide ID
BTDP008712
Peptide Name
Hge-scorpine
Symonym
Hge-scorpine-like 1
Species
Hoffmannihadrurus gertschi (Scorpion) (Hadrurus gertschi)
Uniprot Name
KBX3_HOFGE
Alphafold ID
Q0GY40
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 5IPO
Sequence
MNTKLTVLCFLGIVTIVSCGWMSEKKVQGILDKKLPEGIIRNAAKAIVHKMAKNQFGCFA
NVDVKGDCKRHCKAEDKEGICHGTKCKCGVPISYL
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Sequence Length
95
Mass (Da)
10412
Sequence Removed Signal Peptide
GWMSEKKVQGILDKKLPEGIIRNAAKAIVHKMAKNQFGCFANVDVKGDCKRHCKAEDKEG
ICHGTKCKCGVPISYL
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Disulfide Bond
58-81;68-86;72-88
PDB ID
5IPO , 5JYH
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Caraboctonidae
Genus: Hadrurus
Species: Hadrurus gertschi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1 IC50
185 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.1 IC50
185 nM
 . . [1], [2], [3], [4]
References
Ref 1 Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones). BMC Genomics. 2007 May 16;8:119. doi: 10.1186/1471-2164-8-119.
Ref 2 Wide phylogenetic distribution of Scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of "orphan" components. Peptides. 2007 Jan;28(1):31-7. doi: 10.1016/j.peptides.2006.06.012. Epub 2006 Dec 1.
Ref 3 Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms. Cell Mol Life Sci. 2008 Jan;65(1):187-200. doi: 10.1007/s00018-007-7370-x.
Ref 4 Solution structure and antiparasitic activity of scorpine-like peptides from Hoffmannihadrurus gertschi. FEBS Lett. 2016 Jul;590(14):2286-96. doi: 10.1002/1873-3468.12255. Epub 2016 Jun 30.
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