Peptide Information

General Information of This Peptide
Peptide ID
BTDP008706
Peptide Name
Potassium channel toxin alpha-KTx 6.17
Symonym
Toxin OcyKTx2
Species
Opisthacanthus cayaporum (South American scorpion)
Uniprot Name
KAX6H_OPICY
Alphafold ID
P86116
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P86116
Sequence
IRCQGSNQCYGHCREKTGCMNGKCINRVCKCYGC
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Sequence Length
34
Mass (Da)
3817
Sequence Removed Signal Peptide
IRCQGSNQCYGHCREKTGCMNGKCINRVCKCYGC
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Disulfide Bond
3-24;9-29;13-31;19-34
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Hemiscorpiidae
Genus: Opisthacanthus
Species: Opisthacanthus cayaporum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
17.7 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.3 Dissociation constant
18 nM
 .
Blocker
 [1]
 Target Info    Shaker Dissociation constant
82 nM
 .
Blocker
 [1]
 Target Info    Shaker B potassium channel Dissociation constant
96.6 nM
 .
Blocker
 [1], [2]
References
Ref 1 OcyKTx2, a new K?-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum. Peptides. 2013 Aug;46:40-6. doi: 10.1016/j.peptides.2013.04.021. Epub 2013 May 15.
Ref 2 Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum. Toxicon. 2008 Jun 15;51(8):1499-508. doi: 10.1016/j.toxicon.2008.03.029. Epub 2008 Apr 4.
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