Peptide Information

General Information of This Peptide
Peptide ID
BTDP008698
Peptide Name
Conotoxin vil14a
Symonym
Conotoxin vil14.1
Species
Conus villepinii (Villepin's cone)
Uniprot Name
CREA_CONVL
Alphafold ID
P84704
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6EFE
Sequence
MGFRVLVLVVMATTSALPFTFSEEPGRSPFRPALRSEEAQALRHGLTLLLARRADGQPPD
MRQPEMRRPEMRRPEVRQPEFAETPVGQKRGGLGRCIYNCMNSGGGLSFIQCKTMCY
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Sequence Length
117
Mass (Da)
13143
Sequence Removed Signal Peptide
GGLGRCIYNCMNSGGGLSFIQCKTMCY
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Disulfide Bond
96-116;100-112
PDB ID
6EFE
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus villepinii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    potassium channels . . . . [1], [2]
 Target Info    Kv1.3 Inhibition constant
12.1 μM
 . . [1], [2]
References
Ref 1 Definition of the R-superfamily of conotoxins: Structural convergence of helix-loop-helix peptidic scaffolds. Peptides. 2018 Sep;107:75-82. doi: 10.1016/j.peptides.2018.06.002. Epub 2018 Jul 21.
Ref 2 A novel conotoxin framework with a helix-loop-helix (Cs alpha/alpha) fold. Biochemistry. 2005 Dec 13;44(49):15986-96. doi: 10.1021/bi0511181.
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