Peptide Information

General Information of This Peptide
Peptide ID
BTDP008697
Peptide Name
Potassium channel toxin alpha-KTx 6.13
Symonym
Spinoxin
Species
Heterometrus spinifer (Asia giant forest scorpion) (Malaysian black scorpion)
Uniprot Name
KAX6D_HETSP
Alphafold ID
P84094
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P84094
Sequence
IRCSGSRDCYSPCMKQTGCPNAKCINKSCKCYGC
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Sequence Length
34
Mass (Da)
3709
Sequence Removed Signal Peptide
IRCSGSRDCYSPCMKQTGCPNAKCINKSCKCYGC
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Disulfide Bond
3-24;9-29;13-31;19-34
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Heterometrus
Species: Heterometrus spinifer
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv11 Inhibition rate .
5 μM
Blocker
 [1]
 Target Info    Kv1.2 IC50
2.5 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.3 IC50
69 nM
 .
Blocker
 [3]
References
Ref 1 A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels. Biochem Pharmacol. 2008 Sep 15;76(6):805-15. doi: 10.1016/j.bcp.2008.07.008. Epub 2008 Jul 18.
Ref 2 Scorpion toxins interact with nicotinic acetylcholine receptors. FEBS Lett. 2019 Oct;593(19):2779-2789. doi: 10.1002/1873-3468.13530. Epub 2019 Jul 18.
Ref 3 Active Sites of Spinoxin, a Potassium Channel Scorpion Toxin, Elucidated by Systematic Alanine Scanning. Biochemistry. 2016 May 31;55(21):2927-35. doi: 10.1021/acs.biochem.6b00139. Epub 2016 May 18.
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