Peptide Information

General Information of This Peptide
Peptide ID
BTDP008686
Peptide Name
Kunitz-type kappaPI-theraphotoxin-Hs1a
Symonym
Huwentoxin HW11c5; Huwentoxin-11g8; Huwentoxin-XI; Kunitz-type serine protease inhibitor HWTX-XI-IS5; Kunitz-type serine protease inhibitor huwentoxin-11
Species
Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Uniprot Name
VKT1A_CYRSC
Alphafold ID
P68425
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2JOT
Sequence
MGIARILSAVLFLSVLFVVTFPALLSADHHDGRIDTCRLPSDRGRCKASFERWYFNGRTC
AKFIYGGCGGNGNKFPTQEACMKRCAKA
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Sequence Length
88
Mass (Da)
9721
Sequence Removed Signal Peptide
IDTCRLPSDRGRCKASFERWYFNGRTCAKFIYGGCGGNGNKFPTQEACMKRCAKA
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Disulfide Bond
37-85;46-68;60-81
PDB ID
2JOT
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Cyriopagopus
Species: Cyriopagopus schmidti
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate
10 %
5 μM
Blocker
 [1- 5]
 Target Info    Kv1.2 Inhibition rate
10 %
5 μM
Blocker
 [1- 5]
 Target Info    Kv1.3 Inhibition rate
28 %
5 μM
Blocker
 [1- 5]
 Target Info    Kv1.3 Inhibition rate
28 %
5 μM
Blocker
 [1- 5]
 Target Info    Kv1.1 Inhibition rate
78 %
5 μM
Blocker
 [1- 5]
 Target Info    Kv1.1 Inhibition rate
78 %
5 μM
Blocker
 [1- 5]
 Target Info    Kv1 IC50
11.6 nM
 .
Blocker
 [1- 5]
 Target Info    Kv1.1 IC50
2.57 μM
 .
Blocker
 [1- 5]
References
Ref 1 Genomic organization and cloning of novel genes encoding toxin-like peptides of three superfamilies from the spider Orinithoctonus huwena. Peptides. 2008 Oct;29(10):1679-84. doi: 10.1016/j.peptides.2008.06.001. Epub 2008 Jun 12.
Ref 2 Discovery of a distinct superfamily of Kunitz-type toxin (KTT) from tarantulas. PLoS One. 2008;3(10):e3414. doi: 10.1371/journal.pone.0003414. Epub 2008 Oct 15.
Ref 3 Molecular diversification based on analysis of expressed sequence tags from the venom glands of the Chinese bird spider Ornithoctonus huwena. Toxicon. 2008 Jun 15;51(8):1479-89. doi: 10.1016/j.toxicon.2008.03.024. Epub 2008 Mar 27.
Ref 4 An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)]. Toxicon. 2004 Apr;43(5):575-85. doi: 10.1016/j.toxicon.2004.02.005.
Ref 5 Nuclear magnetic resonance studies on huwentoxin-XI from the Chinese bird spider Ornithoctonus huwena: 15N labeling and sequence-specific 1H, 15N nuclear magnetic resonance assignments. Acta Biochim Biophys Sin (Shanghai). 2006 Jul;38(7):457-66. doi: 10.1111/j.1745-7270.2006.00191.x.
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