Peptide Information

General Information of This Peptide
Peptide ID
BTDP008670
Peptide Name
Potassium channel toxin alpha-KTx 5.4
Symonym
Tamapin
Species
Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus)
Uniprot Name
KAX54_HOTTA
Alphafold ID
P59869
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2KY3
Sequence
AFCNLRRCELSCRSLGLLGKCIGEECKCVPY
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Sequence Length
31
Mass (Da)
3465
Sequence Removed Signal Peptide
AFCNLRRCELSCRSLGLLGKCIGEECKCVPY
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Disulfide Bond
3-21;8-26;12-28
PDB ID
2KY3 , 2LU9 , 2ME7 , 2MEL , 2MEN , 2MEO , 6D3T , 6D8H , 6D8Q , 6D8R , 6D8S , 6D8T , 6D8U , 6D8Y , 6D93 , 6D9O , 6D9P , 6VNZ
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus tamulus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa3.1 Inhibition rate .
50 nM
Blocker
 [1], [2]
 Target Info    KCa3.1 Inhibition rate .
50 nM
Blocker
 [1]
 Target Info    KCa2 IC50
0.024 nM
 .
Blocker
 [1], [2]
 Target Info    KCa2.2 IC50
0.0243 nM
 .
Blocker
 [1], [2]
 Target Info    KCa2.3 IC50
1.7 nM
 .
Blocker
 [1], [2]
 Target Info    KCa2.3 IC50
1.7 nM
 .
Blocker
 [1], [2]
 Target Info    KCa2.1 IC50
42 nM
 .
Blocker
 [1]
 Target Info    KCa2.1 IC50
42 nM
 .
Blocker
 [1], [2]
References
Ref 1 Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons. J Biol Chem. 2002 Nov 29;277(48):46101-9. doi: 10.1074/jbc.M206465200. Epub 2002 Sep 17.
Ref 2 Cytotoxicity of recombinant tamapin and related toxin-like peptides on model cell lines. Chem Res Toxicol. 2014 Jun 16;27(6):960-7. doi: 10.1021/tx4004193. Epub 2014 May 12.
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