Peptide Information

General Information of This Peptide
Peptide ID
BTDP008661
Peptide Name
Kappa-theraphotoxin-Gr1a
Symonym
Hanatoxin-1
Species
Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Uniprot Name
TXHN1_GRARO
Alphafold ID
P56852
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1D1H
Sequence
MKTSVFAAILGLALFAVLCSGSELQEKDLKETLLSAIMETALEAQPEERECRYLFGGCKT
TSDCCKHLGCKFRDKYCAWDFTFSK
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Sequence Length
85
Mass (Da)
9528
Signal Sequence
MKTSVFAAILGLALFAVLCSG
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Sequence Removed Signal Peptide
SELQEKDLKETLLSAIMETALEAQPEERECRYLFGGCKTTSDCCKHLGCKFRDKYCAWDF
TFSK
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Disulfide Bond
51-65;58-70;64-77
PDB ID
1D1H
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Grammostola
Species: Grammostola rosea
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.1 Dissociation constant
102 nM
 .
Modifier
 [1- 7]
 Target Info    Kv3.1 Inhibition rate .
500 nM
Modifier
 [1- 7]
 Target Info    Kv1.1 Inhibition rate .
500 nM
Modifier
 [1- 7]
 Target Info    Kv1.3 Inhibition rate .
500 nM
Modifier
 [1- 7]
 Target Info    Kv1.6 Inhibition rate .
500 nM
Modifier
 [1- 7]
 Target Info    Kv10.1 Inhibition rate .
500 nM
Modifier
 [1- 7]
 Target Info    Kv4.2 IC50
100 nM
 .
Modifier
 [1- 7]
 Target Info    Shaker-IR IC50
6 μM
 .
Modifier
 [1- 7]
References
Ref 1 An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron. 1995 Oct;15(4):941-9. doi: 10.1016/0896-6273(95)90184-1.
Ref 2 Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites. Neuron. 1997 Apr;18(4):665-73. doi: 10.1016/s0896-6273(00)80306-2.
Ref 3 Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron. 1997 Apr;18(4):675-82. doi: 10.1016/s0896-6273(00)80307-4.
Ref 4 Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8585-9. doi: 10.1073/pnas.95.15.8585.
Ref 5 Voltage-sensor activation with a tarantula toxin as cargo. Nature. 2005 Aug 11;436(7052):857-60. doi: 10.1038/nature03873.
Ref 6 Gating modifier peptides as probes of pancreatic beta-cell physiology. Toxicon. 2007 Feb;49(2):231-8. doi: 10.1016/j.toxicon.2006.09.012. Epub 2006 Sep 23.
Ref 7 Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins. J Mol Biol. 2000 Mar 31;297(3):771-80. doi: 10.1006/jmbi.2000.3609.
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