Peptide Information

General Information of This Peptide
Peptide ID
BTDP008649
Peptide Name
Potassium channel toxin Sp4
Species
Scorpiops pococki (Scorpion)
Uniprot Name
KA11N_SCOPC
Alphafold ID
P0DQN4
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQN4
Sequence
MNKVHFALFLLVLTVLAVSGFPSENAPTGGCPLSDNVCSSYCKKNKFGNEGKCHGTICKC
SIK
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Sequence Length
63
Mass (Da)
6709
Sequence Removed Signal Peptide
FPSENAPTGGCPLSDNVCSSYCKKNKFGNEGKCHGTICKCSIK
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Disulfide Bond
31-53;38-58;42-60
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Euscorpiidae
Genus: Scorpiops
Species: Scorpiops pococki
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate
7 %
1 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
7.23 %
1 μM
 . [1]
 Target Info    Kv1.1 Inhibition rate
20.85 %
1 μM
 . [1]
 Target Info    Kv1.1 Inhibition rate
21 %
1 μM
Blocker
 [1]
 Target Info    Kv1.3 IC50
24.73 nM
 . . [1]
 Target Info    Kv1.3 IC50
24.73 nM
 .
Blocker
 [1]
References
Ref 1 Cloning, expression and identification of KTX-Sp4, a selective Kv1.3 peptidic blocker from Scorpiops pococki. Cell Biosci. 2017 Nov 6;7:60. doi: 10.1186/s13578-017-0187-x. eCollection 2017.
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