Peptide Information

General Information of This Peptide
Peptide ID
BTDP008633
Peptide Name
Potassium channel toxin kappa-KTx 2.8
Symonym
HSP053C.2; Toxin HeTx204; Toxin kappa-KTx 2.7
Species
Heterometrus petersii (Asian forest scorpion)
Uniprot Name
KKX28_HETPE
Alphafold ID
P0DJ35
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DJ35
Sequence
GTVYVFLLLLAFGIFTDISNACSEQMDDEDSYEVEKRGNACIEVCLQHTGNPAECDKPCD
K
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Sequence Length
61
Mass (Da)
6748
Signal Sequence
GTVYVFLLLLAFGIFTDISNA
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Sequence Removed Signal Peptide
CSEQMDDEDSYEVEKRGNACIEVCLQHTGNPAECDKPCDK
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Disulfide Bond
41-59;45-55
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Heterometrus
Species: Heterometrus petersii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa2.3 Inhibition rate
5 %
1 μM
Blocker
 [1]
 Target Info    KCa1.1 Inhibition rate
15 %
600 nM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
35 %
1 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
35.1 %
1 μM
Blocker
 [1], [2], [3]
 Target Info    Kv7.1 Inhibition rate
44.9 %
10 μM
Blocker
 [1], [2], [3]
 Target Info    Kv7.1 Inhibition rate
45 %
100 μM
Blocker
 [1]
References
Ref 1 Structural and functional diversity of acidic scorpion potassium channel toxins. PLoS One. 2012;7(4):e35154. doi: 10.1371/journal.pone.0035154. Epub 2012 Apr 12.
Ref 2 Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis. Proteomics. 2010 Jul;10(13):2471-85. doi: 10.1002/pmic.200900763.
Ref 3 Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new -KTX subfamily. Biochem Pharmacol. 2012 May 1;83(9):1307-17. doi: 10.1016/j.bcp.2012.01.021. Epub 2012 Jan 24.
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