Peptide Information

General Information of This Peptide
Peptide ID
BTDP008632
Peptide Name
Potassium channel toxin kappa-KTx 2.7
Symonym
HSP053C.1; Toxin HeTx203; Toxin kappa-KTx 2.6
Species
Heterometrus petersii (Asian forest scorpion)
Uniprot Name
KKX27_HETPE
Alphafold ID
P0DJ34
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DJ34
Sequence
MKTSGTVYVFLLLLAFGIFTDISSACSEQMDDEDSYEVEKRGNACIEVCLQHTGNPAECD
KACDK
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Sequence Length
65
Mass (Da)
7142
Sequence Removed Signal Peptide
GNACIEVCLQHTGNPAECDKACD
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Disulfide Bond
45-63;49-59
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Heterometrus
Species: Heterometrus petersii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv7.1 Inhibition rate
17.8 %
10 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv7.1 Inhibition rate
18 %
100 μM
Blocker
 [2]
References
Ref 1 Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis. Proteomics. 2010 Jul;10(13):2471-85. doi: 10.1002/pmic.200900763.
Ref 2 Structural and functional diversity of acidic scorpion potassium channel toxins. PLoS One. 2012;7(4):e35154. doi: 10.1371/journal.pone.0035154. Epub 2012 Apr 12.
Ref 3 Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins. PLoS One. 2013;8(4):e60201. doi: 10.1371/journal.pone.0060201. Epub 2013 Apr 3.
Ref 4 Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new -KTX subfamily. Biochem Pharmacol. 2012 May 1;83(9):1307-17. doi: 10.1016/j.bcp.2012.01.021. Epub 2012 Jan 24.
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