Peptide Information

General Information of This Peptide
Peptide ID
BTDP008626
Peptide Name
Kunitz-type serine protease inhibitor Hg1
Symonym
Delta-KTx 1.1
Species
Hoffmannihadrurus gertschi (Scorpion) (Hadrurus gertschi)
Uniprot Name
VKT11_HOFGE
Alphafold ID
P0C8W3
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0C8W3
Sequence
MIIFYGLFSILVLTSINIAEAGHHNRVNCLLPPKTGPCKGSFARYYFDIETGSCKAFIYG
GCEGNSNNFSEKHHCEKRCRGFRKFGGK
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Sequence Length
88
Mass (Da)
9855
Signal Sequence
MIIFYGLFSILVLTSINIAEA
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Sequence Removed Signal Peptide
GHHNRVNCLLPPKTGPCKGSFARYYFDIETGSCKAFIYGGCEGNSNNFSEKHHCEKRCRG
FRKFGGK
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Disulfide Bond
29-79;38-62;54-75
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Caraboctonidae
Genus: Hadrurus
Species: Hadrurus gertschi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa1.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate
<50 %
1 μM
Blocker
 [1], [2]
 Target Info    Kv1.2 Inhibition rate
<50 %
1 μM
Blocker
 [1], [2]
 Target Info    KCa2.3 Inhibition rate
20 %
1 μM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate
45 %
1 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
80 %
1 μM
Blocker
 [1], [2]
 Target Info    Kv1.3 IC50
6.2 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
6.2 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.2 IC50
1 μM
 .
Blocker
 [1]
References
Ref 1 Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family. J Biol Chem. 2012 Apr 20;287(17):13813-21. doi: 10.1074/jbc.M112.343996. Epub 2012 Feb 21.
Ref 2 Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones). BMC Genomics. 2007 May 16;8:119. doi: 10.1186/1471-2164-8-119.
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