Peptide Information

General Information of This Peptide
Peptide ID
BTDP008591
Peptide Name
Kappa-actitoxin-Ael2e
Symonym
Toxin APETx4
Species
Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)
Uniprot Name
BDS4_ANTEL
Alphafold ID
C0HL40
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: C0HL40
Sequence
GTTCYCGKTIGIYWFGKYSCPTNRGYTGSCPYFLGICCYPVD
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Sequence Length
42
Mass (Da)
4660
Sequence Removed Signal Peptide
GTTCYCGKTIGIYWFGKYSCPTNRGYTGSCPYFLGICCYPVD
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Disulfide Bond
4-37;6-30;20-38
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Anthopleura
Species: Anthopleura elegantissima
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
1.6 μM
Modifier
 [1]
 Target Info    Kv11 Inhibition rate .
1.6 μM
Modifier
 [1]
 Target Info    Kv1.5 Inhibition rate
17 %
1.6 μM
Modifier
 [1]
 Target Info    Kv1.3 Inhibition rate
27 %
1.6 μM
Modifier
 [1]
 Target Info    Kv2.1 Inhibition rate
39 %
1.6 μM
Modifier
 [1]
 Target Info    Kv1.4 Inhibition rate
66 %
1.6 μM
Modifier
 [1]
 Target Info    Kv10 IC50
1.1 μM
 .
Modifier
 [1]
 Target Info    Kv10 IC50
1.1 μM
 .
Modifier
 [1]
References
Ref 1 APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel K(V)10.1. Mar Drugs. 2017 Sep 13;15(9):287. doi: 10.3390/md15090287.
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