Peptide Information

General Information of This Peptide
Peptide ID
BTDP008552
Peptide Name
Snake venom serine protease HS114
Symonym
BjSP; Thrombin-like enzyme HS114
Species
Bothrops jararaca (Jararaca) (Bothrops jajaraca)
Uniprot Name
VSP14_BOTJA
Alphafold ID
Q5W959
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q5W959
Sequence
MVLVRVVANLLILQLSYAQKVSELVVGGDECNINEHRSLVAIFNSTGFFCSGILLNQEWV
LTASHCDSTNFQMKIGVHSKKTLNQDEQTRNPKEKIFCPNKKNDDALDKDLMLVRLDSPV
SDSEHIAPLSLPSSPPSVGSVCRIMGWGSITPIQKTNPDVPHCANINLLDDAVCRAAYPE
LPAEYRTLCAGVPEGGIDTCNGDSGGPLICNGQFQGIVFYGAHPCGQAPKPGLYTKVIDY
NTWIESVIAGNTAATCPP
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Sequence Length
258
Mass (Da)
27843
Signal Sequence
MVLVRVVANLLILQLSYA
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Sequence Removed Signal Peptide
QKVSELVVGGDECNINEHRSLVAIFNSTGFFCSGILLNQEWVLTASHCDSTNFQMKIGVH
SKKTLNQDEQTRNPKEKIFCPNKKNDDALDKDLMLVRLDSPVSDSEHIAPLSLPSSPPSV
GSVCRIMGWGSITPIQKTNPDVPHCANINLLDDAVCRAAYPELPAEYRTLCAGVPEGGID
TCNGDSGGPLICNGQFQGIVFYGAHPCGQAPKPGLYTKVIDYNTWIESVIAGNTAATCPP
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Disulfide Bond
31-163;50-66;98-256;142-210;174-189;200-225
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Bothrops
Species: Bothrops jararaca
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv10 Inhibition rate
9 %
5 μM
Blocker
 [1]
 Target Info    Kv11.1 Inhibition rate
9.2 %
5 μM
Blocker
 [1], [2], [3], [4]
References
Ref 1 Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities. Sci Rep. 2020 Mar 11;10(1):4476. doi: 10.1038/s41598-020-61258-x.
Ref 2 Molecular cloning of serine proteinases from Bothrops jararaca venom gland. Toxicon. 2005 Jul;46(1):72-83. doi: 10.1016/j.toxicon.2005.03.011.
Ref 3 BjSP, a novel serine protease from Bothrops jararaca snake venom that degrades fibrinogen without forming fibrin clots. Toxicol Appl Pharmacol. 2018 Oct 15;357:50-61. doi: 10.1016/j.taap.2018.08.018. Epub 2018 Aug 24.
Ref 4 Analysis of the ontogenetic variation in the venom proteome/peptidome of Bothrops jararaca reveals different strategies to deal with prey. J Proteome Res. 2010 May 7;9(5):2278-91. doi: 10.1021/pr901027r.
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