Peptide Information

General Information of This Peptide
Peptide ID
BTDP008543
Peptide Name
Potassium channel toxin KTx1
Symonym
ImKTx1
Species
Isometrus maculatus (Lesser brown scorpion) (Scorpio maculatus)
Uniprot Name
CLKTX_ISOMC
Alphafold ID
P0DJL0
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DJL0
Sequence
FLVLLLVSLMCYAEIAEGSQPTECKYGRPCNSDRDCCWEYRCLSSGREYTCKQDPGP
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Sequence Length
57
Mass (Da)
6486
Sequence Removed Signal Peptide
FLVLLLVSLMCYAEIAEGSQPTECKYGRPCNSDRDCCWEYRCLSSGREYTCKQDPGP
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Disulfide Bond
24-37;30-42;36-51
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Isometrus
Species: Isometrus maculatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate
40 %
10 μM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate
40 %
100 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
42 %
10 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
42 %
100 μM
Blocker
 [1]
 Target Info    Kv1.3 IC50
1.7 μM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
1.7 μM
 .
Blocker
 [1]
References
Ref 1 ImKTx1, a new Kv1.3 channel blocker with a unique primary structure. J Biochem Mol Toxicol. 2011 Jul-Aug;25(4):244-51. doi: 10.1002/jbt.20382. Epub 2011 Feb 9.
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