Peptide Information

General Information of This Peptide
Peptide ID
BTDP008532
Peptide Name
Potassium channel toxin alpha-KTx J123
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KA11M_MESMA
Alphafold ID
B5KF99
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: B5KF99
Sequence
MNKVYLVAVLVLFLALTINESNEAVPTGGCPFSDFFCAKRCKDMKFGNTGRCTGPNKTVC
KCSI
   Click to Show/Hide
Sequence Length
64
Mass (Da)
6953
Signal Sequence
MNKVYLVAVLVLFLALTINESNEA
   Click to Show/Hide
Sequence Removed Signal Peptide
VPTGGCPFSDFFCAKRCKDMKFGNTGRCTGPNKTVCKCSI
   Click to Show/Hide
Disulfide Bond
30-52;37-60;41-62
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate
20 %
1 μM
Blocker
 [1]
 Target Info    KCa2.2 Inhibition rate
24 %
100 μM
Blocker
 [1]
 Target Info    KCa2.3 Inhibition rate
27 %
100 μM
Blocker
 [1]
 Target Info    Kv1.3 IC50
0.79 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
0.8 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
26.4 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
26.4 nM
 .
Blocker
 [1]
References
Ref 1 Characterization of a new Kv1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch. Peptides. 2008 Sep;29(9):1514-20. doi: 10.1016/j.peptides.2008.04.021. Epub 2008 May 13.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.