Peptide Information

General Information of This Peptide
Peptide ID
BTDP008527
Peptide Name
Potassium channel toxin alpha-KTx 9.4
Symonym
BTK-2
Species
Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus)
Uniprot Name
KAX94_HOTTA
Alphafold ID
P60209
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2KTC
Sequence
VGCAECPMHCKGKMAKPTCENEVCKCNIGKKD
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Sequence Length
32
Mass (Da)
3456
Sequence Removed Signal Peptide
VGCAECPMHCKGKMAKPTCENEVCKCNIGKKD
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Disulfide Bond
3-19;6-24;10-26
PDB ID
2KTC
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus tamulus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 IC50
4.6 μM
 .
Blocker
 [1]
References
Ref 1 BTK-2, a new inhibitor of the Kv1.1 potassium channel purified from Indian scorpion Buthus tamulus. FEBS Lett. 2003 Mar 27;539(1-3):7-13. doi: 10.1016/s0014-5793(03)00125-x.
Ref 2 Solution structure of BTK-2, a novel hK(v)1.1 inhibiting scorpion toxin, from the eastern Indian scorpion Mesobuthus tamulus. Biochim Biophys Acta. 2011 Apr;1814(4):459-69. doi: 10.1016/j.bbapap.2011.01.006. Epub 2011 Jan 21.
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