Peptide Information

General Information of This Peptide
Peptide ID
BTDP008503
Peptide Name
Potassium channel toxin alpha-KTx 4.4
Symonym
Toxin Tc30; Toxin To30
Species
Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Uniprot Name
KAX44_TITOB
Alphafold ID
P60210
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P60210
Sequence
VFINVKCRGSKECLPACKAAVGKAAGKCMNGKCKCYP
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Sequence Length
37
Mass (Da)
3878
Sequence Removed Signal Peptide
VFINVKCRGSKECLPACKAAVGKAAGKCMNGKCKCYP
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Disulfide Bond
7-28;13-33;17-35
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus obscurus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
16 nM
 .
Blocker
 [1]
 Target Info    Shaker Dissociation constant
74 nM
 .
Blocker
 [1]
References
Ref 1 Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities. Biochim Biophys Acta. 2002 Dec 16;1601(2):123-31. doi: 10.1016/s1570-9639(02)00458-2.
Ref 2 Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 15;803(1):55-66. doi: 10.1016/j.jchromb.2003.09.002.
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