Peptide Information

General Information of This Peptide
Peptide ID
BTDP008497
Peptide Name
Potassium channel toxin alpha-KTx 3.5
Symonym
Kaliotoxin-2
Species
Androctonus australis (Sahara scorpion)
Uniprot Name
KAX35_ANDAU
Alphafold ID
P45696
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6AY7
Sequence
MKVFSAVLIILFVCSMIIGINAVRIPVSCKHSGQCLKPCKDAGMRFGKCMNGKCDCTPK
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Sequence Length
59
Mass (Da)
6393
Signal Sequence
MKVFSAVLIILFVCSMIIGINA
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Sequence Removed Signal Peptide
VRIPVSCKHSGQCLKPCKDAGMRFGKCMNGKCDCTPK
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Disulfide Bond
29-49;35-54;39-56
PDB ID
6AY7
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Androctonus
Species: Androctonus australis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa Dissociation constant
135 nM
 .
Blocker
 [1], [2]
 Target Info    KCa1.1 Dissociation constant
1.56 μM
 .
Blocker
 [2]
 Target Info    Kv1 IC50
0.05 nM
 .
Blocker
 [2]
References
Ref 1 The kaliotoxin family enlarged. Purification, characterization, and precursor nucleotide sequence of KTX2 from Androctonus australis venom. J Biol Chem. 1994 Dec 30;269(52):32835-43.
Ref 2 Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26.
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