Peptide Information

General Information of This Peptide
Peptide ID
BTDP008493
Peptide Name
Potassium channel toxin alpha-KTx 28.1
Symonym
Toxin ImKTx104
Species
Isometrus maculatus (Lesser brown scorpion) (Scorpio maculatus)
Uniprot Name
KA281_ISOMC
Alphafold ID
R4GUQ3
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2LIX
Sequence
MNFWVTFIRLIVVLSIVFAFQIAVAKAACVTHEDCTLLCYDTIGTCVDGKCKCM
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Sequence Length
54
Mass (Da)
6006
Signal Sequence
MNFWVTFIRLIVVLSIVFAFQIAVAKA
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Sequence Removed Signal Peptide
ACVTHEDCTLLCYDTIGTCVDGKCKCM
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Disulfide Bond
29-46;35-51;39-53
PDB ID
2LIX
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Isometrus
Species: Isometrus maculatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv7.1 Dissociation constant
11.69 μM
 .
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
7 %
1 μM
Blocker
 [1]
 Target Info    Kv7.1 IC50
11.69 μM
 .
Blocker
 [1]
References
Ref 1 Structural and functional diversity of acidic scorpion potassium channel toxins. PLoS One. 2012;7(4):e35154. doi: 10.1371/journal.pone.0035154. Epub 2012 Apr 12.
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