Peptide Information

General Information of This Peptide
Peptide ID
BTDP008471
Peptide Name
Potassium channel toxin alpha-KTx 18.1
Symonym
Toxin Tc32; Toxin To32
Species
Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Uniprot Name
KA181_TITOB
Alphafold ID
P60211
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2JP6
Sequence
MRFTGIILILISMTLIDSFFEMKVEATGPQTTCQAAMCEAGCKGLGKSMESCQGDTCKCK
A
   Click to Show/Hide
Sequence Length
61
Mass (Da)
6530
Signal Sequence
MRFTGIILILISMTLIDSFFEMKVEA
   Click to Show/Hide
Sequence Removed Signal Peptide
TGPQTTCQAAMCEAGCKGLGKSMESCQGDTCKCKA
   Click to Show/Hide
Disulfide Bond
33-52;38-57;42-59
PDB ID
2JP6
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus obscurus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
10 nM
 .
Blocker
 [2]
 Target Info    Shaker Dissociation constant
4.7 μM
 .
Blocker
 [2]
References
Ref 1 Proteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions. PLoS One. 2018 Mar 21;13(3):e0193739. doi: 10.1371/journal.pone.0193739. eCollection 2018.
Ref 2 Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities. Biochim Biophys Acta. 2002 Dec 16;1601(2):123-31. doi: 10.1016/s1570-9639(02)00458-2.
Ref 3 Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 15;803(1):55-66. doi: 10.1016/j.jchromb.2003.09.002.
Ref 4 Looking over toxin-K(+) channel interactions. Clues from the structural and functional characterization of -KTx toxin Tc32, a Kv1.3 channel blocker. Biochemistry. 2012 Mar 6;51(9):1885-94. doi: 10.1021/bi201713z. Epub 2012 Feb 27.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.