Peptide Information

General Information of This Peptide
Peptide ID
BTDP008409
Peptide Name
Kunitz-type serine protease inhibitor homolog beta-bungarotoxin B2 chain
Symonym
Beta-2-bungarotoxin
Species
Bungarus multicinctus (Many-banded krait)
Uniprot Name
VKTH2_BUNMU
Alphafold ID
P00989
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1BUN
Sequence
MSSGGLLLLLGLLTLCAELTPVSSRKRHPDCDKPPDTKICQTVVRAFYYKPSAKRCVQFR
YGGCNGNGNHFKSDHLCRCECLEYR
   Click to Show/Hide
Sequence Length
85
Mass (Da)
9568
Signal Sequence
MSSGGLLLLLGLLTLCAELTPVSS
   Click to Show/Hide
Sequence Removed Signal Peptide
RKRHPDCDKPPDTKICQTVVRAFYYKPSAKRCVQFRYGGCNGNGNHFKSDHLCRCECLEY
R
   Click to Show/Hide
Disulfide Bond
31-81;40-64;56-77;79
PDB ID
1BUN
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Bungarus
Species: Bungarus multicinctus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1 Effective concentration 50
3 nM
 .
Blocker
 [7]
References
Ref 1 Cloning and functional expression of B chains of beta-bungarotoxins from Bungarus multicinctus (Taiwan banded krait). Biochem J. 1998 Aug 15;334 ( Pt 1)(Pt 1):87-92. doi: 10.1042/bj3340087.
Ref 2 Divergence of genes encoding B chains of beta-bungarotoxins. Toxicon. 2006 Mar;47(3):322-9. doi: 10.1016/j.toxicon.2005.11.009. Epub 2006 Feb 2.
Ref 3 Genetic organization of A chain and B chain of beta-bungarotoxin from Taiwan banded krait (Bungarus multicinctus). A chain genes and B chain genes do not share a common origin. Eur J Biochem. 2000 Aug;267(15):4668-75. doi: 10.1046/j.1432-1327.2000.01518.x.
Ref 4 Amino acid sequence of beta 2-bungarotoxin from Bungarus multicinctus venom. The amino acid substitutions in the B chains. J Biochem. 1982 May;91(5):1519-30. doi: 10.1093/oxfordjournals.jbchem.a133843.
Ref 5 The non-phospholipase A2 subunit of beta-bungarotoxin plays an important role in the phospholipase A2-independent neurotoxic effect: characterization of three isotoxins with a common phospholipase A2 subunit. Biochem J. 1994 Oct 1;303 ( Pt 1)(Pt 1):171-6. doi: 10.1042/bj3030171.
Ref 6 Structure of beta 2-bungarotoxin: potassium channel binding by Kunitz modules and targeted phospholipase action. Structure. 1995 Oct 15;3(10):1109-19. doi: 10.1016/s0969-2126(01)00246-5.
Ref 7 Potassium channel blockade by the B subunit of beta-bungarotoxin. Mol Pharmacol. 1990 Aug;38(2):164-9.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.