Peptide Information

General Information of This Peptide
Peptide ID
BTDP008384
Peptide Name
Kappa-ctenitoxin-Pn1a
Symonym
Neurotoxin Tx3-1; PNTx3-1; PhKv
Species
Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Uniprot Name
TX20A_PHONI
Alphafold ID
O76200
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: O76200
Sequence
MWFKIQVLVLAITLITLGIQAEPNSSPNNPLIVEEDRAECAAVYERCGKGYKRCCEERPC
KCNIVMDNCTCKKFISELFGFGK
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Sequence Length
83
Mass (Da)
9379
Signal Sequence
MWFKIQVLVLAITLITLGIQA
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Sequence Removed Signal Peptide
EPNSSPNNPLIVEEDRAECAAVYERCGKGYKRCCEERPCKCNIVMDNCTCKKFISELFGF
GK
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Disulfide Bond
40-55;47-60;54-71;62-69
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Ctenidae
Genus: Phoneutria
Species: Phoneutria nigriventer
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KvAP . . . . [1], [2], [3], [4]
References
Ref 1 Phoneutria nigriventer toxin Tx3-1 blocks A-type K+ currents controlling Ca2+ oscillation frequency in GH3 cells. J Neurochem. 1999 Apr;72(4):1472-81. doi: 10.1046/j.1471-4159.1999.721472.x.
Ref 2 Purification and amino acid sequences of six Tx3 type neurotoxins from the venom of the Brazilian 'armed' spider Phoneutria nigriventer (Keys). Toxicon. 1993 Jan;31(1):35-42. doi: 10.1016/0041-0101(93)90354-l.
Ref 3 Comparison of the partial proteomes of the venoms of Brazilian spiders of the genus Phoneutria. Comp Biochem Physiol C Toxicol Pharmacol. 2006 Mar-Apr;142(3-4):173-187. doi: 10.1016/j.cbpc.2005.09.010. Epub 2005 Nov 8.
Ref 4 Antiarrhythmogenic effects of a neurotoxin from the spider Phoneutria nigriventer. Toxicon. 2011 Feb;57(2):217-24. doi: 10.1016/j.toxicon.2010.11.013. Epub 2010 Nov 27.
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